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Esomeprazole Magnesium Trihydrate IP equivalent to Esomeprazole – 40 mg (as enteric coated pellets)
Colour: Titanium Dioxide IP Domperidone IP – 30 mg (as sustained-release pellets)
Colours: Sunset Yellow Supra & Sunset Yellow Lake Approved colours used in capsule shells.
Larsoz-DSR is prescribed for the treatment of
Gastroesophageal reflux disease (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use. For management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.
About the drug:
Esomeprazole is the S-isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell.
Domperidone is a peripheral-specific antagonist of the dopamine receptor D2 (D2R), with antiemetic, gastrokinetic and galactagogue activities. Following administration, domperidone binds to D2R expressed by peripheral neurons; this inhibits dopamine binding and D2R-mediated signaling. Inhibition of peripheral D2R signaling prevents or relieves various gastrointestinal (GI) symptoms, such as nausea and vomiting, and may help relief reflux and symptoms of a variety of other upper GI disorders.
Dosage :
Larsoz-DSR capsule should be taken once daily on empty stomach before breakfast or at least 1 hour before meals as directed by a physician.
Usage Direction :
The capsules should be swallowed whole with liquid. The capsules should not be opened or chewed or crushed.
It is recommended to take Larsoz-DSR before meals.
Patients should try to take each dose at the scheduled time. If a scheduled dose is missed, the missed dose should be omitted, and the usual dosing schedule resumed. The dose should not be doubled to make up for a missed dose.
Do not consume more than the prescribed quantity.
If allergic to Esomeprazole or Domperidone inform the same physician immediately.
Side Effects of Larsoz-DSR
The most common side effects are vomiting, heartburn, stomach upset, rash, itching, breathing difficulty, and nasal inflammation. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. Avoid drinking alcohol while taking this medicine as that may cause excessive drowsiness.
Storage
Store at a temperature not exceeding 30°C. Protect from light and moisture. Keep out of reach of children.
Safety Advice
ALCOHOL
Caution is advised when consuming alcohol with Larsoz-DSR Capsule. Please consult your doctor.
PREGNANCY
CONSULT YOUR DOCTOR
Larsoz-DSR Capsule may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
BREASTFEEDING
CONSULT YOUR DOCTOR
Larsoz-DSRCapsule is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breast milk in a significant amount and is not harmful to the baby.
DRIVING
Larsoz-DSR Capsule may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
LIVER
Larsoz-DSR Capsule should be used with caution in patients with liver disease. Dose adjustment of Larsoz-DSR Capsule may be needed. Please consult your doctor.
Use of Larsoz-DSRCapsule is not recommended in patients with moderate and severe liver disease.
KIDNEY
Larsoz-DSRCapsule should be used with caution in patients with kidney disease. Dose adjustment of Larsoz-DSRCapsule may be needed. Please consult your doctor.
If you miss a dose of Larsoz-DSR capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
If you find difficulty in getting this brand in your nearby area pharmacies please contact our help line number through whatsapp8297223334. We will help you in availability.